Concepedia

New evidence for cofactor’s amino group function in thiamin catalysis by transketolase

L. E. Meshalkina, G.A. Kochetov, Johanna Brauer, Gerhard Hübner, Kai Tittmann, Ralph Golbik

Biochemical and Biophysical Research Communications · 2007 · 10 citations · 16 references

DOI

Concepts

References

16

How Thiamine Diphosphate Is Activated in Enzymes

Dorothee Kern, Günther Kern, Holger Neef et al. · Science · 1997 · 290 citations

, , +16

Refined Structure of Transketolase from Saccharomyces cerevisiae at 2·0 Å Resolution

Matti Nikkola, Ylva Lindqvist, G. Schneider · Journal of Molecular Biology · 1994 · 191 citations

, , +7

NMR Analysis of Covalent Intermediates in Thiamin Diphosphate Enzymes

Kai Tittmann, Ralph Golbik, Kathrin Uhlemann et al. · Biochemistry · 2003 · 139 citations

, , +17

Analysis of an invariant cofactor-protein interaction in thiamin diphosphate-dependent enzymes by site-directed mutagenesis. Glutamic acid 418 in transketolase is essential for catalysis.

Christer Wikner, L. E. Meshalkina, Urban Nilsson et al. · Journal of Biological Chemistry · 1994 · 121 citations · Full text

, , +15

Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from <i>Saccharomyces cerevisiae</i>

Erik Fiedler, Stina Thorell, Tatyana Sandalova et al. · Proceedings of the National Academy of Sciences · 2002 · 119 citations

, , +17