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Amide protection and amide supports in solid-phase peptide synthesis
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1970
Year
Medicinal ChemistryBioorganic ChemistryBiochemistryAmide ProtectionMedicineNatural SciencesPeptoidSide-chain Amide FunctionsPeptide EngineeringPeptide LibraryPeptide SynthesisOrganic ChemistryPeptide ScienceC-terminal Amide PeptidesPeptide ChemistryGastrin TetrapeptidePharmacologyBiomolecular Engineering
A protecting group for side-chain amide functions, and polymeric amino-supports for use in the synthesis of C-terminal amide peptides, have been developed, and their use demonstrated in the syntheses of gastrin tetrapeptide by the solution and the solid-phase procedures.