Concepedia

A Sequential Metal-Catalyzed C−N Bond Formation in the Synthesis of 2-Amido-indoles

Peiyuan Yao, Yu Zhang, Richard P. Hsung, Kang Zhao

Organic Letters · 2008 · 93 citations · 78 references

DOI

Concepts

Abstract

A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.

References

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