Journal of Morphology · 1925 · 396 citations · 9 references
MedicineAnatomyDevelopmental BiologyEmbryogenesisMorphogenesisOrganogenesisBone DevelopmentBone FormationCartilage BiologyLimb DevelopmentOsteogenesisSkeletal DevelopmentLimb Cartilage DevelopmentLimb OssificationLong Bone DevelopmentLong Bone OssificationMultinucleated Giant CellsOsteogenesis In Limbs
The study describes cartilage and bone development in fowl limbs from the 52nd hour of incubation to one day post‑hatching. The authors found that chondroblasts die during cartilage resorption, long bones contain mammalian‑like epiphyseal structures, endochondral ossification is limited to epiphyses and diaphyseal ends, and marrow cavities harbor multinucleated giant cells formed by fusion of degenerating cells.
Abstract The development and cytology of cartilage and bone in the limbs from the fifty‐second hour of incubation to the first day after hatching are described. The chief points of interest arising from this study are: (1) Chondroblasts when liberated during cartilage resorption die and disintegrate. (2) All the long bones possess structures which, though not undergoing independent ossification, are homologous with the mammalian epiphyses. (3) Endochondral ossification occurs only in the epiphyses and ends of the diaphyses. (4) The marrow cavity contains multinucleated giant cells which appear to be formed by the fusion of degenerating cells.
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Eben J. Carey · Journal of Morphology · 1922 · 52 citations