The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

Hua Lu, Osvaldo Flores, Roberto Weinmann, Danny Reinberg

Proceedings of the National Academy of Sciences · 1991 · 321 citations · 34 references

Concepts

Abstract

The two forms of RNA polymerase II that exist in vivo, phosphorylated (IIO) and nonphosphorylated (IIA), were purified to apparent homogeneity from HeLa cells. The nonphosphorylated form preferentially binds to the preinitiation complex. RNA polymerase II in the complex was converted by a cellular protein kinase to the phosphorylated form.

References

34