HEME OXYGENASE-1 OVEREXPRESSION PROTECTS RAT HEARTS FROM COLD ISCHEMIA/REPERFUSION INJURY VIA AN ANTIAPOPTOTIC PATHWAY1

Abstract

HO-1 overexpression provides potent protection against cold I/R injury in a stringent rat cardiac model. This effect depends, at least in part, on HO-1-mediated up-regulation of a host antiapoptotic mechanism, especially in the early postreperfusion period.