Concepedia

Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD

Quan Du, Nicolas Carrasco, Marianna Teplova, Christopher J. Wilds, Martin Egli, Zhen Huang

Journal of the American Chemical Society · 2001 · 102 citations · 10 references

DOI

Concepts

Abstract

We have developed a route for the synthesis of 2'-selenium uridine analogues and oligonucleotides containing selenium labels, and have demonstrated for the first time a new strategy to covalently derivatize nucleotides with selenium for phase and structure determination in X-ray crystallography.

References

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