Concepedia

Human MHC Class I-restricted high avidity CD4<sup>+</sup>T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

Shao‐An Xue, Liquan Gao, Maryam Ahmadi, Sara Ghorashian, Rafael Di Marco Barros, Constandina Pospori, Angelika Holler, Graham P. Wright, Sharyn Thomas, Max S. Topp,

OncoImmunology · 2012 · 51 citations · 35 references

DOIFull text

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Concepts

Abstract

T cells capable of providing MHC Class I-restricted immunity against MHC Class II-negative tumors in vivo.

References

35

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

Richard A. Morgan, Mark E. Dudley, John R. Wunderlich et al. · Science · 2006 · 2.6K citations · Full text

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Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

Paul F. Robbins, Richard A. Morgan, Steven A. Feldman et al. · Journal of Clinical Oncology · 2011 · 1.6K citations · Full text

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Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

Naomi Hunder, Herschel Wallen, Jianhong Cao et al. · New England Journal of Medicine · 2008 · 905 citations · Full text

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Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Sergio A. Quezada, Tyler R. Simpson, Karl S. Peggs et al. · The Journal of Experimental Medicine · 2010 · 887 citations · Full text

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Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids

Russell D. Salter, David N. Howell, Peter Cresswell · Immunogenetics · 1985 · 570 citations

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