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Synthesis and 5-Hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines

Gregory S. Welmaker, James A. Nelson, Joan Sabalski, Annmarie L. Sabb, John R. Potoski, Denise Graziano, Michael Kagan, Joseph Coupet, John Dunlop, Hossein Mazandarani,

Bioorganic & Medicinal Chemistry Letters · 2000 · 40 citations · 6 references

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References

6

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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5-HT 2C receptor activation decreases appetite and body weight in obese subjects

Peter A. Sargent, Ann L. Sharpley, Clare Williams et al. · Psychopharmacology · 1997 · 155 citations

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Potencies of antagonists indicate that 5‐HT<sub>1C</sub> receptors mediate 1–3(chlorophenyl)piperazine‐induced hypophagia

G.A. Kennett, G. Curzon · British Journal of Pharmacology · 1991 · 149 citations · Full text

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Current and Potential Drugs for Treatment of Obesity

George A. Bray · Endocrine Reviews · 1999 · 111 citations

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Stereoselective synthesis of substituted pipecolic acids

Steven R. Angle, Damian O. Arnaiz · Tetrahedron Letters · 1989 · 52 citations

, , +4