Chemische eigenschaften und synthese‐verfahren von 3‐vinylindolen

Abstract

Abstract Selectively functionalized 3‐vinylindoles are mostly stable compounds, which may serve as potent building blocks for anellation of the indole nucleus, in particular for synthesis of carbazole alkaloides and to obtain pharmacologically active compounds. This review describes from a great number of the permanent increasing literature of vinylheterocycles the chemical properties, the most important principles of the synthetic methods and the synthetic applications of 3‐vinylindoles. Among the synthetic methods to obtain 3‐vinylindoles the classical condensation, the Wittig‐Horner‐/Wadsworth‐Emmons‐Olefination and the recently developed Pd‐catalyzed vinylation should be considered as reliable standard methods. Depending on the special functionalization in the desired product some others methodologies are developed, so the thermolysis or the acid catalyzed ipso ‐cleavage of hetarylindolylethanes for deriving 1‐hetaryl‐1‐indolylethenes.