Possible mechanisms of action of the aqueous extract of<i>Artocarpus altilis</i>(breadfruit) leaves in producing hypotension in normotensive Sprague–Dawley rats

Abstract

A. altilis exhibits negative chronotropic and hypotensive effects through α-adrenoceptor and Ca²⁺ channel antagonism. Drug adversity effects are unlikely if the aqueous leaf extract is consumed with other medications reliant on CYP3A4 and CYP2D6 metabolism. This study thus provides scientific evidence for the use of the breadfruit in the treatment of hypertension.