Polysaccharide derivatives as chiral stationary phases in HPLC

Abstract

Abstract Twenty different tris(phenylcarbamate)s of cellulose were synthesized and evaluated as chiral stationary phases for HPLC. Optical resolving power of the tris(phenylcarbamate)s depends on the substituents introduced on the phenyl groups. Optical resolving abilities of amylose tris(phenylcarbamate)s were also evaluated. In most cases, either cellulose tris(3,5‐dimethylphenylcarbamate) or amylose tris(3,5‐dimethylphenylcarbamate) exhibited the highest optical resolving ability. Aralkylcarba‐mates such as benzyl‐ and 1‐phenylethylcarbamates of cellulose and amylose were also tested as chiral stationary phases. ( S )‐1‐Phenylethylcarbamate of amylose showed a high optical resolving power.