Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

The atlas of mouse development

Rosa Beddington · Trends in Genetics · 1993 · 1.4K citations

Life Sciences, Biology, Developmental Biology +12

Expression of Multidrug Resistance Gene in Human Cancers

Lori J. Goldstein, Hanan Galski, Antonio Tito Fojo et al. · JNCI Journal of the National Cancer Institute · 1989 · 1.3K citations

Medicine, Cancer Biology, Oncology +11

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15