Concepedia

Design and activity of AP endonuclease-1 inhibitors

Zhiwei Feng, Stanton J. Kochanek, David A. Close, Lirong Wang, Ajay Srinivasan, Abdulrahman A. Almehizia, Prema Iyer, Xiang‐Qun Xie, Paul A. Johnston, Barry Gold

Journal of Chemical Biology · 2015 · 31 citations · 45 references

Open access

Concepts

PharmacyMedicinal ChemistryMolecular BiologyDrug DesignDrug DiscoveryEnzymologyCovalent Inhibitor DesignEnzyme InhibitionLead Compound DesignNucleic Acid Drug DesignPotency OptimizationEndonuclease MechanismsEndoribonucleolytic CleavageMechanism-based Lead Optimization

References

45

A smooth particle mesh Ewald method

Ulrich Essmann, L. Perera, Max L. Berkowitz et al. · The Journal of Chemical Physics · 1995 · 22.9K citations

Natural Sciences, Chemistry, Biomolecular Modeling +13

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

Bernard R. Brooks, Robert E. Bruccoleri, Barry D. Olafson et al. · Journal of Computational Chemistry · 1983 · 14.9K citations

Natural Sciences, Chemistry, Biomolecular Modeling +13

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins

Alexander D. MacKerell, Donald Bashford, M. Bellott et al. · The Journal of Physical Chemistry B · 1998 · 14.5K citations

Natural Sciences, Biophysics, Chemistry +17

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman, Axel Hauschild, Caroline Robert et al. · New England Journal of Medicine · 2011 · 7.7K citations · Full text

Medicine, Molecular Genetics, Oncology +9

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting‐Chao Chou · Cancer Research · 2010 · 5.7K citations

Pharmacy, Pharmacokinetics, Pharmacology +15