Chemoenzymatic Synthesis of Carbasugars (+)-Pericosines A−C from Diverse Aromatic <i>cis</i>-Dihydrodiol Precursors

Abstract

cis-Dihydrocatechols, derived from biological cis-dihydroxylation of methyl benzoate, iodobenzene and benzonitrile, using the microorganism Pseudomonas putida UV4, were converted into pericosines A, C, and B, respectively. This approach constitutes the shortest syntheses, to date, of these important natural products with densely packed functionalities.