Blockade of PDGFR-β activation eliminates morphine analgesic tolerance

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

Drug Target, Signal Transduction, Medicine +6

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

Annika B. Malmberg, Tony L. Yaksh · Pain · 1993 · 384 citations

Formalin Injection, Pain Medicine, Neuropathic Pain +20

Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux

HaiQing Dai, Peter Marbach, Michel Lemaire et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 270 citations

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

Andreas Herrlich, Henrik Daub, Axel Knebel et al. · Proceedings of the National Academy of Sciences · 1998 · 157 citations