Nonsurgical Cerebrospinal Fluid Rhinorrhea in Invasive Macroprolactinoma: Incidence, Radiological, and Clinicopathological Features

Abstract

The incidence of nonsurgical CSF rhinorrhea in MPRL patients (8.7%) is higher than expected. Dopamine agonist resistance is more common in MPRLs with CSF rhinorrhea; however, whether this is a mechanistic relationship requires further study. Protease-activated receptor 1 expression, e-cadherin expression, and macrophage infiltration rates do not distinguish tumors with from those without CSF rhinorrhea.