Effect of a Nonionic Surface-Active Agent on Blood Viscosity and Platelet Adhesiveness

Abstract

The effects of Pluronic F68, a nonionic surface-active agent, on blood viscosity and platelet adhesiveness during extracorporeal circulation were investigated. Blood viscosity was significantly decreased. Platelet adhesiveness decreased markedly in six patients within ten minutes after intravenous injection. Pluronic F68 has many properties and actions which make it a useful additive to perfusion systems. Its potential in the treatment of diseases in which high viscosity or increased platelet adhesiveness are present deserves investigation.