Polyaspartamide — a potential drug carrier

Abstract

Abstract The molecular weight of polysuccinimide prepared by thermal polycondensation depends mostly on the reaction temperature. Antioxidants have no effect. Proteolytic enzymes do not degrade the main chain of N ‐substituted polyaspartamides tested. Bacteria are capable of utilizing about 4% of aspartic acid from the 2‐hydroxyethyl derivative. Side chains are sensitive to enzymes as in the previously studied polyolefinic polymers.