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SUCCESSFUL THERAPY OF NIEMANN-PICK DISEASE BY IMPLANTATION OF HUMAN AMNIOTIC MEMBRANE
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1987
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InfertilityDevelopmental BiologyTransplantationXenotransplantationLysosomal Storage DisorderSuccessful TherapyImplantation (Embryology)GynecologyHuman Embryonic DevelopmentBiomedical EngineeringMedicineCell BiologyLysosomal Storage DiseasePure Epithelial CellsReplacement Therapy
In a patient with a lysosomal storage disorder, not involving the CNS, repeated implantations of human amniotic sheets have proved to provide a successful approach to enzyme replacement therapy. Implantation of pure epithelial cells, separated from the other cell types of the amnion, might markedly improve the procedure, avoiding some risks of host-versus-graft rejection.