MESOGLYCAN TREATMENT RESTORES DEFECTIVE FIBRINOLYTIC POTENTIAL IN CUTANEOUS NECROTIZING VENULITIS

Abstract

These data suggest that reduced CFA may play a major role in the pathogenesis of the immunologically mediated injury in CNV. The intraperivascular deposition of fibrin is favored. The fibrinolytic agent mesoglycan seems effective in restoring defective fibrinolysis in patients affected by cutaneous necrotizing venulitis, suggesting that in cases with reduced cutaneous fibrinolytic activity (or potential) the use of a fibrinolytic agent should be considered.