Human Skin Fibroblasts Derived from Papillary and Reticular Dermis: Differences in Growth Potential in Vitro

Abstract

Papillary fibroblasts, when compared to reticular fibroblasts from the same skin specimen, exhibit greater proliferative capacities in vitro. These results demonstrate a difference in function between morphologically similar cells obtained from the same tissue. Such findings represent an important consideration in the study of cell aging in vitro.