Effects of met-enkephalin on body temperature of normal and morphine-tolerant rats

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Purification and properties

Brian M. Cox, K E Opheim, H. Teschemacher et al. · Life Sciences · 1975 · 1.7K citations

Analgesia induced in vivo by central administration of enkephalin in rat

James D. Belluzzi, Norman H. Grant, Victor M. Garsky et al. · Nature · 1976 · 528 citations

Medicine, Pharmacology, Neuropharmacology +11

An endogenous morphine-like factor in mammalian brain

Gavril W. Pasternak, Robert Goodman, Solomon H. Snyder · Life Sciences · 1975 · 393 citations

Life Sciences, Neurobiology, Neuroscience +14

Isolation

H. Teschemacher, K E Opheim, Brian M. Cox et al. · Life Sciences · 1975 · 285 citations