Metformin interacts with AMPK through binding to γ subunit

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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Metformin and reduced risk of cancer in diabetic patients

Josie Evans, Louise A. Donnelly, Alistair Emslie‐Smith et al. · BMJ · 2005 · 2.4K citations · Full text

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy et al. · Proceedings of the National Academy of Sciences · 2004 · 1.8K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Angela Woods, Kristina Dickerson, Richard Heath et al. · Cell Metabolism · 2005 · 1.4K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Ripudaman S. Hundal, Sylvie Dufour, Didier Laurent et al. · Diabetes · 2000 · 1.1K citations · Full text

Life Sciences, Endocrinology, Physiology +17