Synthesis of antibiotics (cephaloglycin) catalyzed by penicillin G acylase: Evaluation and optimization of different synthetic approaches

Aldehyde-agarose gels as activated supports for immobilization-stabilization of enzymes

JoséM. Guisán · Enzyme and Microbial Technology · 1988 · 594 citations

Engineering, Biochemical Engineering, Biotechnology +5

Mechanism and yields in enzyme catalysed equilibrium and kinetically controlled synthesis of β-lactam antibiotics, peptides and other condensation products

Volker Kasche · Enzyme and Microbial Technology · 1986 · 364 citations

Controlled Synthesis, β-Lactam Antibiotics, Biochemistry +8

Immobilization-stabilization of Penicillin G acylase fromEscherichia coli

Gregorio Álvaro, Roberto Fernández‐Lafuente, Rosa M. Blanco et al. · Applied Biochemistry and Biotechnology · 1990 · 149 citations

Molecular Biotechnology, Engineering, Biochemical Engineering +4

Enzyme reaction engineering: Synthesis of antibiotics catalysed by stabilized penicillin G acylase in the presence of organic cosolvents

Roberto Fernandez-Lafuente, Cristina M. Rosell, JoséM. Guisán · Enzyme and Microbial Technology · 1991 · 89 citations

Biosynthesis, Engineering, Biochemistry +9

[26] Equilibrium and kinetically controlled synthesis with enzymes: Semisynthesis of penicillins and peptides

Volker Kasche, Ursula Haufler, Lutz Riechmann · Methods in enzymology on CD-ROM/Methods in enzymology · 1987 · 87 citations

Biosynthesis, Bioorganic Chemistry, Engineering +9