Concepedia

Solution conformational analysis, crystal structure determination, and anticancer activity of ring-constrained 1,3,2-dioxa- and oxazaphosphorinane cyclophosphamide analogues

Ji-Charng Yang, Dinesh O. Shah, Nuti Uma Maheswara Rao, Wade A. Freeman, George Soenovsky, David G. Gorenstein

Tetrahedron · 1988 · 29 citations · 32 references

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignOrganic ChemistryStructure-activity RelationshipsChemical Space ExplorationConformational AnalysisCrystal ChemistryHeterocyclic ChemistryLigand-based DesignStructure-activity Relationship AnalysisAnticancer ActivityAnticancer ChemotherapyCrystal Structure DeterminationStructure-based Ligand Design

References

32

Reagents for Organic Synthesis

Richard C. Larock · Journal of Organometallic Chemistry · 1976 · 2.3K citations

Natural Sciences, Chemical Engineering, Chemistry +5

PROTOCOLS FOR SCREENING CHEMICAL AGENTS AND NATURAL PRODUCTS AGAINST ANIMAL TUMORS AND OTHER BIOLOGICAL SYSTEMS

Ruth I. Geran, Nathaniel H. Greenberg, Marylea MacDonald et al. · Cancer chemotherapy reports. Part 1 · 1972 · 1.1K citations

Medicine, Medicinal Chemistry, Pharmacology +8

Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.

Donald L. Hill, W R Laster, Robert F. Struck · PubMed · 1972 · 181 citations

Medicine, Biochemistry, Pharmacology +17

Metabolism of cyclophosphamide

N Brock, H. J. Hohorst · Cancer · 1967 · 160 citations · Full text

Pharmacy, Biochemistry, Pharmacology +13

Urinary Metabolites of the Antitumor Agent Cyclophosphamide

Robert F. Struck, Marion Kirk, L.B. Mellett et al. · Molecular Pharmacology · 1971 · 107 citations

Medicine, Pharmacology, Cancer Pharmacology +8