Two cytotoxic pentacyclic triterpenoids from Nerium oleander

Abstract

The isolation and structure elucidation of two novel cytotoxic pentacyclic triterpenoids cis-karenin (3β-hydroxy-28-Z-p-coumaroyloxy-urs-12-en-27-oic acid) and trans-karenin (3-β-hydroxy-28-E-p-coumaroyloxy-urs-12-en-27-oic acid) from the leaves of Nerium oleander is described.