New 1,3-dioxolane and 1,3-dioxane derivatives as effective modulators to overcome multidrug resistance

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

Dominic A. Scudiero, Robert H. Shoemaker, Kenneth D. Paull et al. · PubMed · 1988 · 2.4K citations

Chemoprevention Strategy, Pathology, Cell Culture +22

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

John M. Zamora, Homer L. Pearce, William T. Beck · Molecular Pharmacology · 1988 · 414 citations

Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption

Janice Hunter, Barry H. Hirst · Advanced Drug Delivery Reviews · 1997 · 291 citations

Health Sciences, Intestinal Secretion, Gastrointestinal Pharmacology +11

Structure–activity relationship of P-glycoprotein substrates and modifiers

Anna Seelig, Ewa Landwojtowicz · European Journal of Pharmaceutical Sciences · 2000 · 276 citations

Glycoproteomics, Protein Chemistry, Biochemistry +6

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

Homer L. Pearce, Ahmad R. Safa, Nicholas J. Bach et al. · Proceedings of the National Academy of Sciences · 1989 · 234 citations · Full text

Drug Target, P-glycoprotein Pharmacophore, Pharmacotherapy +18