A new class of selective, non-basic 5-HT2A receptor antagonists

The Antipsychotic Agent Sertindole is a High Affinity Antagonist of the Human Cardiac Potassium Channel HERG

David Rampe, Michael Murawsky, Eric Lewis · Journal of Pharmacology and Experimental Therapeutics · 1998 · 175 citations

Medicine, Cardiology, Pharmacology +15

Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation.

C D Wang, Tim Gallaher, J C Shih · Molecular Pharmacology · 1993 · 144 citations

Medicine, Medicinal Chemistry, Pharmacology +14

A Highly Conserved Aspartic Acid (Asp-155) Anchors the Terminal Amine Moiety of Tryptamines and Is Involved in Membrane Targeting of the 5-HT2A Serotonin Receptor But Does Not Participate in Activation via a “Salt-Bridge Disruption” Mechanism

Kurt Kristiansen, Wesley K. Kroeze, David L. Willins et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 117 citations

Life Sciences, Molecular Biology, Pharmacology +17

4-(Phenylsulfonyl)piperidines:  Novel, Selective, and Bioavailable 5-HT_2AReceptor Antagonists

Stephen R. Fletcher, Frank Burkamp, Peter Blurton et al. · Journal of Medicinal Chemistry · 2001 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents

Lüpei Du, Keng‐Chang Tsai, Minyong Li et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 39 citations · Full text

Medicine, Cardiology, Pharmacology +14