Concepedia

Role of Indian Hedgehog Signaling in Palatal Osteogenesis

Benjamin Levi, Aaron W. James, Emily R. Nelson, Samantha A. Brugmann, Michael Sorkin, Alina Manu, Michael T. Longaker

Plastic & Reconstructive Surgery · 2011 · 31 citations · 28 references

DOIFull text

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Abstract

The authors' results suggest a role for hedgehog signaling during palatal ossification. The hedgehog pathway is activated during palatal fusion, and deletion of Indian hedgehog leads to diminished ossification of the secondary hard palate.

References

28

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

Benoit St‐Jacques, Matthias Hammerschmidt, Andrew P. McMahon · Genes & Development · 1999 · 1.7K citations · Full text

Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants

Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science · 1997 · 1.7K citations

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Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

Juhee Jeong, Junhao Mao, Toyoaki Tenzen et al. · Genes & Development · 2004 · 628 citations · Full text

MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans

Marie‐José H. van den Boogaard, M. Dorland, Frits A. Beemer et al. · Nature Genetics · 2000 · 584 citations

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Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

Bradley W. Doble, Satish Patel, Geoffrey A. Wood et al. · Developmental Cell · 2007 · 445 citations · Full text

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