2012 · 14 citations · 9 references
MedicineAnatomyNeuroscienceBiomedical ImagingHistologyVolume Visualization3D ReconstructionBrain ImagingImage ReconstructionImage RegistrationMedical ImagingThree-dimensional ReconstructionAnatomical Co-registrationAtlas-based ReconstructionCo-registrationDeformable RegistrationHistological StructureMedical Image RegistrationThree-dimensional Image ReconstructionThree-dimensional Medical Imaging
In this paper, we present methods for the reconstruction of 3D histological volumes of the human hippocampal formation from histology slices. Inter-slice alignment is guided by a graph-theoretic approach that minimizes the impact of badly distorted slices. The reconstruction is refined by iterative affine and deformable co-registration with a high-resolution MRI of the postmortem tissue sample. We present an evaluation of reconstruction accuracy that is based on measures of similarity between boundaries drawn on both histology and MRI. Our methodology is currently being applied to an MRI atlas of the human hippocampal formation, in which atlas anatomical labels are derived from segmentation of reconstructed histology.
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Genome-wide atlas of gene expression in the adult mouse brain
Ed S. Lein, Michael Hawrylycz, Nancy Ao et al. · Nature · 2006 · 6K citations