Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat

Ethical guidelines for investigations of experimental pain in conscious animals

M. Zimmermann · Pain · 1983 · 7.8K citations

Medicine, Anesthesiology, Animal Sciences +14

Chronic catheterization of the spinal subarachnoid space

Tony L. Yaksh, Thomas A. Rudy · Physiology & Behavior · 1976 · 2.2K citations

Medicine, Neurological Surgery, Neurosurgery +12

The involvement of glial cells in the development of morphine tolerance

Ping Song, Zhi‐Qi Zhao · Neuroscience Research · 2001 · 444 citations

Medicine, Neurobiology, Neuroscience +14

A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

Ian N. Johnston, Erin D. Milligan, Julie Wieseler‐Frank et al. · Journal of Neuroscience · 2004 · 429 citations · Full text

Medicine, Anesthesiology, Pharmacology +17

Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain

Jianren Mao, Donald D. Price, David J. Mayer · Pain · 1995 · 329 citations

Medicine, Neuroscience, Pharmacology +17