Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Christine C. Hudson, Mei Liu, Gary G. Chiang et al. · Molecular and Cellular Biology · 2002 · 1.2K citations · Full text

Medicine, Oncology, Pharmacology +15

Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

Alexandra Giatromanolaki, Michael I. Koukourakis, Efthimios Sivridis et al. · British Journal of Cancer · 2001 · 472 citations · Full text

Medicine, Molecular Biology, Oncology +16

Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib

Floriana Morgillo, Jong Kyu Woo, Edward S. Kim et al. · Cancer Research · 2006 · 336 citations · Full text

Medicine, Oncology, Pharmacology +17

The hypoxia-inducible factor-1α is a negative factor for tumor therapy

Annika Unruh, Anke Ressel, Hamid G Mohamed et al. · Oncogene · 2003 · 333 citations

Medicine, Cancer Biology, Oncology +16

Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1α

Roderick J. Phillips, Javier Mestas, Mehrnaz Gharaee‐Kermani et al. · Journal of Biological Chemistry · 2005 · 320 citations · Full text

Medicine, Cell Biology, Oncology +17