Hydroxamic acid and fluorinated derivatives of valproic acid: Anticonvulsant activity, neurotoxicity and teratogenicity

A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS

J.T. LITCHFIELD, Frank Wilcoxon · Journal of Pharmacology and Experimental Therapeutics · 1949 · 7.3K citations

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Atomic physicochemical parameters for three-dimensional-structure-directed quantitative structure-activity relationships. 2. Modeling dispersive and hydrophobic interactions

Arup K. Ghose, Gordon M. Crippen · Journal of Chemical Information and Computer Sciences · 1987 · 808 citations

Pharmacy, Chemistry, Computational Chemistry +15

Valproate Induces Replication-independent Active DNA Demethylation

Nancy Detich, Veronica Bovenzi, Moshe Szyf · Journal of Biological Chemistry · 2003 · 345 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid

Elke Jäger‐Roman, A Deichl, S Jakob et al. · The Journal of Pediatrics · 1986 · 282 citations

Medicine, Obstetrics, Pediatrics +17

The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.

Juliette G. C. Omtzigt, Frans J. Los, Diederick E. Grobbee et al. · PubMed · 1992 · 256 citations

Medicine, Maternal Health, Obstetrics +15