Antihyperglycemic effect of equol, a daidzein derivative, in cultured L6 myocytes and <i>ob</i>/<i>ob</i> mice

Abstract

The hypoglycemic effect of equol is related to increased GLUT4 translocation to the plasma membrane via AMPK activation. In addition, equol suppresses the fasting blood glucose level and gene expression of hepatic enzymes related to glucose metabolism. These results strongly suggest that equol has antidiabetic potential.