Mechanism of Action of Thrombin on Fibrinogen, I. Synthesis of Fibrinogen-like Peptides, and Their Proteolysis by Thrombin and Trypsin

Abstract

In a study of the action of thrombin on fibrinogen and a comparison of this enzyme with trypsin, several fibrinogen-like oligopeptides were synthesized. The hydrolysis of the arginyl-glycine bond in these peptides, by both of these enzymes, is examined and compared.