Major Injury Induces Increased Production of Interleukin-10 by Cells of the Immune System With a Negative Impact on Resistance to Infection

Abstract

Serious injury in humans and in a mouse burn model is followed by increased stimulated production of IL-10 by cells of the immune system. The CD4+ T-helper cells appear to be a major source of IL-10 after injury. In injured patients, increased IL-10 production is correlated with subsequent septic events, and in the burn mouse, IL-10 appears to induce decreased resistance to infection.