Synthesis and biological activity of novel series of heterocyclic compounds containing succinimide moiety

Abstract

Abstract In the search for biological agents, a series of new N -substituted ethyl 11-ethyl-7-methyl-3,5,10-trioxo-4-azatricyclo[5.2.2.0 2,6 ]undecane-8-carboxylates 3 , 9-methyl-3,5,8-trioxo-4-azatricyclo[5.2.1.0 2,6 ]dec-1-yl acetates 6 and 1,3-dioxo-4,5,6,7-tetraphenyl-2,3,3a,4,5,7a-hexahydro-1 H -isoindole-4-carboxylic acids 9 were prepared. All compounds were characterized by 1 H NMR, ESI-MS, and elemental analyses. Moreover, for intermediate products 2 , 5 , and 8 , X-ray structural analyses were conducted. Compounds 3a–e , 6a, 6b , 9a–e were tested for their cytotoxic properties in K562 and HeLa cells.