EFFECT OF HISTAMIN ON GASTRIC SECRETION

Abstract

Histamin has a markedly stimulating effect on gastric secretion. This action of the drug on cats and dogs was observed by Popielski, 1 Keeton, Koch and Luckhardt, 2 Lim, 3 Rothlin and Gundlach, 4 and Ivy, McIlvain and Javois, 5 and the same observation was made on the stomach of man by Carnot, Koskowski and Libert, 6 and by Matheson and Ammon. 7 By subcutaneous injection of the drug and periodic aspiration of t[ill] gastric contents, Matheson and Ammon found that there was an increased flow of gastric juice accompanied by an increase of free hydrochloric acid, total acidity and peptic activity. In this study, the effect of histamin on gastric secretion was observed in seventeen subjects, of whom six were normal. The remaining eleven had presented achlorhydria in a single fractional test meal (arrowroot crackers, 40 gm., and water, 400 c.c.), with aspirations at fifteen-minute intervals during the second