Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation

Richard W. Burg, Brinton M. Miller, Jerome Birnbaum et al. · Antimicrobial Agents and Chemotherapy · 1979 · 940 citations · Full text

Medicine, Microbiology, Pharmacology +16

Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector

Douglas J. MacNeil, Keith M. Gewain, Carolyn L. Ruby et al. · Gene · 1992 · 761 citations

Life Sciences, Biotechnology, Microbiology +9

Engineered Biosynthesis of Novel Polyketides

Robert McDaniel, Susanne Ebert‐Khosla, David A. Hopwood et al. · Science · 1993 · 470 citations

Engineering, Biochemistry, Biotechnology +16

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

Robert McDaniel, Arinthip Thamchaipenet, Claes Gustafsson et al. · Proceedings of the National Academy of Sciences · 1999 · 461 citations

Engineering, Biological Engineering, Biotechnology +17

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in <i>Streptomyces</i> <i>avermitilis</i>

Haruo Ikeda, Tomoko Nonomiya, Masayo Usami et al. · Proceedings of the National Academy of Sciences · 1999 · 349 citations · Full text

Life Sciences, Microbiology, Molecular Biology +12