Concepedia

A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2

John Hamilton, Iain Jones, Rajeev Srivastava, Peter Galloway

Clinica Chimica Acta · 2012 · 181 citations · 10 references

DOIFull text

Open access

Abstract

Measurement of LAL using DBS is made difficult by the presence of other lipases in whole blood. Lalistat 2 is a specific inhibitor of LAL which allows the determination of LAL in DBS. Results show the method differentiates clearly between normal controls, carriers and affected cases.

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