Phase I study to determine the safety and pharmacokinetics of oral administration of TAS‐102 in patients with solid tumors

Abstract

The authors' study showed that 50 mg/m2/day was a tolerable dose of the novel antimetabolite FTD in combination with an inhibitor of its inactivating enzyme TP, and this is the recommended Phase II dose. Evaluation of this daily dose in malignancies for which fluoropyrimidines have failed is needed.