Mechanical Stretch Via Transforming Growth Factor-β1 Activates MicroRNA208a to Regulate Endoglin Expression in Cultured Rat Cardiac Myoblasts

Abstract

Cyclic mechanical stretch enhances miR208a expression in cultured rat cardiac myoblasts. The stretch-induced miR208a is mediated by TGF-β1. Mir208a activates endoglin expression and may result in cardiac fibrosis.