Group sequential designs for one-sided and two-sided hypothesis testing with provision for early stopping in favor of the null hypothesis

A Multiple Testing Procedure for Clinical Trials

Peter C. O’Brien, Thomas R. Fleming · Biometrics · 1979 · 3.3K citations

Public Health, Biostatistics, Evidence-based Practice +13

Group sequential methods in the design and analysis of clinical trials

Stuart Pocock · Biometrika · 1977 · 1.8K citations

Public Health, Biostatistics, Experimental Design +13

Discrete sequential boundaries for clinical trials

K. K. Gordon Lan, David L. DeMets · Biometrika · 1983 · 1.7K citations

Business, Biostatistics, Decision Sciences +10

Discrete Sequential Boundaries for Clinical Trials

K. K. Gordon Lan, David L. DeMets · Biometrika · 1983 · 1.7K citations

Business, Biostatistics, Decision Sciences +10

Repeated Significance Tests on Accumulating Data

P. Armitage, C. K. McPherson, Beverley Charles Rowe · Journal of the Royal Statistical Society Series A (General) · 1969 · 779 citations

Natural Sciences, Biostatistics, Experimental Design +14