Angewandte Chemie International Edition · 1999 · 380 citations · 0 references
Natural SciencesBiochemistryChemistryCatalysisEnzymologyInorganic ChemistryBioinorganic ChemistryCarbonyl ComplexesCatalytic MechanismsCoordination ChemistryEnzyme-substrate RecognitionMetal-ligand BondingActive Site AnalysisActive Site CharacterizationBioinorganic ModelsIron CatalysisIron-sulfur ChemistryIron-sulfur Cluster EnzymesOrganometallic ComplexesStructural Model Selection
The Fe(I) organometallic complex [(µ-SCH(2)CH(2)CH(2)S)Fe(2)(CO)(6)] provides a structural model for the cyano-carbonyl diiron site of Fe-only hydrogenase as characterized by X-ray crystallography (the picture shows the structure (black) of the model overlaid with that of the Fe-Fe dimetallic site in the hydrogenase isolated from Desulfovibrio desulfuricans). Cyanide substitution of CO occurs readily and provides spectroscopic references for the active site.