American Journal of Anatomy · 1981 · 232 citations · 26 references
Life SciencesAnatomyDevelopmental BiologyDevelopmental AnatomyMorphogenesisOrganogenesisLung DevelopmentMammalian AnatomyPulmonary AnatomyPulmonary PhysiologyRespiratory AnatomyRespiratory System DevelopmentAcinar StructureCuboidal Epithelial DifferentiationCuboidal EpitheliumDevelopmental Lung AnatomyFetal Lung DevelopmentLung GrowthPostnatal Lung DevelopmentPulmonary Maturation
The pseudoglandular, canalicular, terminal‑sac, and alveolar periods are traditionally thought to correspond to the formation of distinct components of the pulmonary acinus. The study aims to evaluate and revise the mammalian‑lung developmental model by proposing a new period scheme based on recent epithelial findings in the CPB‑S mouse strain and a tentative human lung scheme. The authors examined epithelial morphology across pre‑ and postnatal stages in CPB‑S mice, using histological analysis to delineate the pseudoglandular, canalicular, terminal‑sac, and alveolar periods and to derive a revised developmental framework. Epithelial evidence indicates that the pseudoglandular period initiates acinar tubule formation, from which all acinus components arise, and that the traditional period divisions are not supported, with respiratory development proceeding by acinar tubule budding in an undetermined pattern.
Abstract To evaluate one model of mammalian‐lung development, i.e., division into periods, pre‐ and postnatal lung development in the CPB‐S mouse strain was divided into the currently distinguished periods: the pseudoglandular period, covering establishment of the air‐conducting portion; and the canalicular, terminal‐sac, and alveolar or postnatal periods, in which the respiratory portion develops. The last three periods would each cover the formation of a different component of the respiratory unit or pulmonary acinus (acinus pulmonaris) (nonalveolated respiratory bronchiole, nonalveolated duct and sac, and alveolar pouch). However, determination of the nature of the relevant structures on the basis of recent findings concerning the epithelia showed that these hypotheses are not tenable. Since the tubule with cuboidal epithelium (appearing in the pseudoglandular and following periods) is the basic structure in the genesis of the pulmonary acinus, the development of the respiratory portion must start in the pseudoglandular period. Likewise, since the definitive components of the acinus are derived from this acinar tubule, their establishment may not be restricted to one of the other periods. Because other postulated divisions of mammalian‐lung development were based on similar histological interpretations, they cannot reflect the course of mouse‐lung development either. Therefore, a developmental scheme based on the recent findings concerning the epithelia is given as well as a tentative scheme for the human lung. The respiratory portion proved to develop by budding of acinar tubules, the mode of budding being not restricted to any particular pattern.
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The postnatal growth of the rat lung III. Morphology
Peter H. Burri · The Anatomical Record · 1974 · 342 citations
Postnatal growth of the mouse lung.
Amy Rw, D Bowes, Burri Ph et al. · PubMed · 1977 · 277 citations