Histopathological evidence for an association of inflammation with ductal pin‐like lesions but not with ductal adenocarcinoma in the prostate of the noble rat

Abstract

Even though adenocarcinomas were not morphologically associated with inflammation, PIN-like lesions preceding adenocarcinoma were found in close association with inflammation, pointing towards a possible initiator role of inflammation in the early steps of prostatic carcinogenesis. Further, these results indicate that both androgens and estrogens together play a significant role in the induction of inflammation and prostatic cancer in this model.