Expression of Leukotriene C₄ Synthase and Plasminogen Activator Inhibitor 1 Gene Promoter Polymorphisms in Sinusitis

Abstract

There appears to be a genetic component that contributes to nasal polyp formation in sinusitis. Although the LTC4S polymorphism has previously been associated with aspirin-sensitive asthma, this is the first demonstration that the polymorphism is associated with CHES and this is independent of aspirin sensitivity.