Observation of the Coexistence of Sodium and Calcium Ions in a DNA G-Quadruplex Ion Channel

Michael P. H. Lee, Gary N. Parkinson, Pascale Hazel, Stephen Neidle

Journal of the American Chemical Society · 2007 · 74 citations · 7 references

Concepts

Abstract

The crystal structure of a DNA quadruplex, d(TGGGGT), crystallized in the presence of calcium and sodium ions, shows the presence of both ions in the central channel of the structure. This was verified by anomalous dispersion maps, which unequivocally showed the presence of calcium ions.

References

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