The pharmacokinetics of polymer-bound adriamycin

Effect of molecular weight (M_<i>w</i>) of<i>N</i>‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

Leonard W. Seymour, Ruth Duncan, J. Strohalm et al. · Journal of Biomedical Materials Research · 1987 · 429 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Chemotherapy through Lysosomes with a DNA-Daunorubicin Complex

André Trouet, D. Deprez-De Campeneere, Christian de Duve · Nature New Biology · 1972 · 269 citations

Medicine, Oncology, Pharmacology +12

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies.

A. Trouet, Michèle Masquelier, R. Baurain et al. · Proceedings of the National Academy of Sciences · 1982 · 233 citations

Medicine, Oncology, Pharmacology +16

Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles

Patrick Couvreur, Boubacar Kanté, L. Grislain et al. · Journal of Pharmaceutical Sciences · 1982 · 213 citations

Pharmacy, Pharmacology, Toxicology +14

Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side‐chains in poly[<i>N</i>‐(2‐hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes

Ruth Duncan, Hazel C. Cable, John B. Lloyd et al. · Die Makromolekulare Chemie · 1983 · 194 citations

Life Sciences, Biochemistry, Pharmacology +17